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In Crohn's Disease, the small intestine can be heavily inflamed which can reduce absorption of many nutrients, including vitamin B12

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A PMC review confirmed structured physical activity produced the strongest CRF reductions across all cancer types, outperforming both pharmaceutical interventions and rest-based strategies (PMC)

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Here's the TL;DR on vitamin timing: while there is no official medical advice dictating that you should take vitamin supplements at a specific time of day to improve their efficiency, there is quite a lot of research showing that avoiding some vitamin supplements at particular times (or more accurately, with particular meals) can improve absorption, or that taking some vitamins alongside food can reduce the risk of adverse side effects