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For instance, if your indigestion stems from a food intolerance, a targeted enzyme might shine, but for broader gut issues like irritable bowel syndrome (IBS), supplements alone may fall short.18 Below, we break down some common enzymes found in supplements: Amylases, proteases, and lipases Amylases, proteases, and lipases are the core enzymes your body uses to digest carbohydrates, proteins, and fats.15 19 Salivary glands, the stomach, the pancreas, and the small intestine all contribute, so most people with normal digestive function already have substantial built-in capacity to break down mixed meals.12 Supplemental versions of these enzymes usually appear together in broad-spectrum blends rather than as single-ingredient products.20 A Mayo Clinic review notes that data on over-the-counter (OTC) digestive enzyme is limited and that most trials test multi-enzyme formulas, with benefits that are statistically significant but generally modest.21 Additionally, while two randomized, double-blind, placebo-controlled studies in people with functional dyspepsia found that multi-enzyme complexes including amylases, proteases, and lipase improved post-meal pain, fullness, and bloating compared with placebo, not everyone responded and average effect sizes were small.7 8 Taken together, these findings suggest that extra amylases, proteases, and lipase may be worth a cautious trial if your symptoms clearly flare after eating, but current evidence doesnt support them as a universal solution for all digestive complaints

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