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Yes, under medical supervision

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'During the season, creatine is probably not the best idea, as it just gives you extra weight, extra water and extra muscle mass. Other ergogenic supplements include HMB, an amino acid that prevents muscle protein breakdown, and L-carnitine, which reduces fatigue and helps convert fats into energy

When someone has an MTHFR mutation it handicaps the efficiency of the methylation cycle by up to 90%