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Together, these findings underscore that while Treg dysfunction is a central feature of many autoimmune diseases, the broader immune context, including aberrant B cell activity, Th17-driven inflammation, dysregulated innate immunity, and cytokine imbalance, converges to shape severe disease pathogenesis
Looking from 2023 to 2024, the latest year of data available, prescriptions and gross spending for Wegovy (first approved for obesity in 2021, approved for cardiovascular disease in 2024) and Mounjaro (approved for type 2 diabetes in 2022) more than doubled, and prescriptions and gross spending for Zepbound (first approved for obesity in 2023, approved for sleep apnea in 2024) increased more than fivefold
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The Gila monster version Eng isolated exendin-4 lasted for hours because the lizard, which eats only a few times a year, evolved a hormone that could hang around and squeeze every calorie out of a rare meal
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