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Its core symptoms (extenuating fatigue, post exertional exacerbation, cognitive dysfunction, sleep disorders and pain) are shared with the other PAIS (68), but no unique, identified pathogen appears responsible for its triggering

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Cavadias I, Maitrot-Mantelet L, Perol S, et al

The reduced risk of several CNS disorders were estimated by hazard ratios and they were modestly decreased for alcohol use disorder, cannabis use disorder, stimulant use disorder, opioid use disorder, suicidal ideation of self-injury, bulimia, schizophrenia, seizures and neurocognitive disorders

Additional research found the hormone acts on the nervous system rather than regulating arousal through the vascular system like medications such as Viagra and Cialis