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Both are interesting from a longevity standpoint specifically because theyre not foreign compounds theyre things your body made abundantly when you were younger
thus, dose reduction strategies (e.g., taking 100 mcg from Monday to Saturday but skipping Sunday) may not have been accurately captured
Chang C-H, Tsai W-C, Lin M-S, Hsu Y-H, Su J-H
Lower doses may be appropriate for those with liver disease or low body weight (under 50kg)
Plenty of people find that three small meals is genuinely all they want, and if those three meals are getting you to your protein target, there is no prize for adding a fourth eating occasion you did not ask for
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