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Phase 2 (Astrup 2008, Lancet) Design Randomized, double-blind, placebo-controlled trial in 203 obese adults across five Danish centers

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Step 2: Gradual Dose Escalation Treatment begins at a low starting dose, typically around 0.25 mg per week, increasing gradually every 4 weeks toward a maintenance dose often in the range of 1.7 mg to 2.4 mg weekly, depending on individual response and tolerance

Notably, orforglipron exhibited the highest risk, followed by exenatide, tirzepatide, semaglutide, and liraglutide