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The tripeptide glutathione, -L-glutamyl-L-cysteinyl-glycine, has come to the forefront as a nutritional bioactive with potential use in the management of NAFLD, as it plays a critical role in cellular antioxidant and detoxification systems
K.JinL.KaranthN.SunY.AbramovaN.et al (2004)
P-rank scores show that SGLT-2 inhibitors were ranked first in reducing nonfatal MI (90.4%) (Additional file 1: Table S2)
2023;306(2):e220749
The mechanism by which toxicity results is complex, but is believed to involve reaction between unconjugated NAPQI and critical proteins as well as increased susceptibility to oxidative stress caused by the depletion of glutathione
