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GSH From Antioxidant to Post-Translational Modifier (PMC, 2016) S-Glutathionylation as a Major Redox Signalling Mechanism A review published in PMC, authored by a leading researcher in the field, documented GSHs evolution in the scientific literature from a simple antioxidant to a key post-translational modifier through S-glutathionylation the reversible formation of mixed disulfides between GSH and protein cysteine residues

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In addition, blockade of sodium channels, high-voltage calcium currents, carbonic anhydrase isoenzymes, and mitochondrial permeability transition pore (MPTP) may also contribute to its neuroprotective effects