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The short plasma half-life (~14 minutes) means peak levels are transient, which is why weekly or biweekly protocols are common in clinical practice
In seven large cardiovascular studies, all agents shown at least non-inferiority, with liraglutide, subcutaneous semaglutide, and dulaglutide revealing statistically significant decreases in cardiovascular outcomes (Sheahan et al
10.1093/eurheartj/ehad192 60 MossadD
Both the patient and the clinician were provided with written and verbal information about the clinical aspects of semaglutide and metformin
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