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Since there is an established link between disrupted melatonin rhythms and the risk of AD dementia [41, 42], investigating the potential therapeutic role of melatonin in addressing these issues is a promising area of research and intervention for AD

Based on this, in the subsequent I/R- and TMT-induced myocardial injury model, the drug not only enhanced GSH levels and GPX and GST activities to lower oxidative damage but also reduced TMT-induced pyroptosis and I/R-mediated apoptosis [205,206,207]

A clinical review noted that orally administered glutathione "cannot be relied upon for therapeutic purposes," which is why researchers and clinicians have used precursor strategies (NAC, GlyNAC) or IV delivery to achieve meaningful systemic increases

Quintanal-Villalonga, A

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