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Beyond engaging canonical hypothalamic and hindbrain networks that control metabolic homeostasis, GLP1RAs recruit a discrete population of Glp1r -expressing neurons in the central amygdala, which selectively suppress the consumption of palatable foods by reducing dopamine release in the nucleus accumbens
By making people feel full, it means they reduce their overall calorie intake
People might lose an average of 2% of their body weight each month during this period
In the STEP 1 trial, 44% of participants reported nausea and 24% reported vomiting (Wilding et al., NEJM, 2021)
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