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If Fe 2+ is overloaded, the Fenton reaction will occur with LOOH to produce alkyl free radicals, instigating lipid peroxidation [30, 32]

Because studies have evaluated GHK-Cu across multiple cell types (including fibroblasts and keratinocytes) and in preclinical models, it is commonly used to support mechanistic work on aging-related tissue changes, repair biology, and copper homeostasisstrictly within controlled research designs

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10.1038/s41433-020-0806-3 Eye (Lond)