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Osmoelectric siphon models for signal and water dispersal in wounded plants

Gastroenterology 136 , 13491358 (2009)

Irisin activates SIRT1 to deacetylate HIF-1, reducing lactate metabolism and cell apoptosis To explore how irisin regulates HIF-1 through SIRT1, we used co-immunoprecipitation to isolate HIF-1 and measured its acetylation status

This multi-receptor approach distinguishes it from existing licensed medicines such as semaglutide (Ozempic, Wegovy) or tirzepatide licensed in the UK as Mounjaro for type 2 diabetes and as Zepbound for obesity which act on fewer receptor pathways

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