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Analytical Framework and Evidence Grading Individual estimates from included meta-analyses were re-analyzed using fixed-effect and random-effects models
Based on clinical trial data: Common: Nausea (22-40%most common complaint) Flushing (14-17%) Headache (9-14%) Injection site reactions Less common: Vomiting Fatigue Dizziness Serious concerns: Transient blood pressure increases Hyperpigmentation with frequent use Contraindicated in uncontrolled hypertension or cardiovascular disease The nausea can be dose-limiting for some individuals
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