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Higher doses of GLP-1, often prescribed for obesity management, can intensify gastrointestinal symptoms
For studies in DIO mice, male C57BL/6J mice were fed with a high-fat diet comprising 58% kilocalories from fat (D12331, Research Diets)
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This suggests that GPR43 and GPR41 may not be part of the mechanism required for GLP-1 and PYY release from SCFAs
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