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Autophagy promotes ferroptosis by degradation ferritin
Minimize temperature cycling (repeated warm/cool changes) to help reduce degradation risk
The FDA added it to injectable semaglutide in January 2025, and it climbs the dose axis like everything else. Burning or tingling skin tracks the dose, not the weight lost, and an active-comparator study put the risk about twice that of another weight-loss drug. The mechanism remains unsettled
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The trials studied it as a standalone
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