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This is because: Older adults make less stomach acid, which is needed for B12 absorption
Future medicinal chemistry efforts may yield next-generation compounds with enhanced properties, including improved tissue selectivity, modified pharmacokinetics, or additional mechanistic activities that complement NNMT inhibition
However, there are common mistakes that can impact both the effectiveness of the treatment and patient safety
Some health issues can change how much B12 is needed
In aging research, the compound provides a unique approach to investigating theories of metabolic decline, as NNMT expression increases with age in many tissues, potentially contributing to the NAD+ decline associated with aging processes
