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Cell 2011

Ergogdu showed that incubation of human coronary artery endothelial cells (HCAECs) with exendin-4 caused an increase in DNA synthesis and cell proliferation through PKA-PI3K/Akt-eNOS activation pathways via a GLP-1 receptor-dependent mechanism [106]

doi: 10.1172/jci.insight.140532 110 ZhaoFZhouQCongZHangKZouXZhangCet al

However, greater efficacy often came with a higher risk of gastrointestinal adverse events