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For a 220-pound person, that is 33 to 37 pounds

NNMT consumes S-adenosylmethionine (SAM) as a methyl donor, so inhibiting NNMT could theoretically increase SAM availability for other methylation reactions

Therefore, it is a powerful tool for obesity and metabolic disorder investigations

This is especially true for individuals who live in areas with limited sunlight exposure or have conditions that affect their ability to absorb vitamin D from food

Some diseases that make you at higher risk of having a deficiency include gastritis, digestive diseases such as celiac disease or Crohns disease, HIV, or an alcohol abuse disorder