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Some neurological symptoms may continue improving for up to 1218 months, though permanent damage can occur if deficiency was severe and prolonged

Limitation: Oral supplements must pass through the digestive tract, and a significant portion of nutrients can be lost during digestion

[72] The anti-pernicious anemia factor was only isolated from the liver by Smith, Rex, and others

Week 24+ Maximum clinical efficacy

B12 deficiency can also lead to the destruction of immature red blood cells in the bone marrow, which can cause jaundice (yellowing of the skin and whites of the eyes)