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Summary: Taking too much Ozempic (semaglutide) causes intensified gastrointestinal symptoms and may lead to hypoglycaemia, particularly in patients on combination diabetes therapy

This particularly useful in assessing cellular response to oxidative stress and toxicity

For weight management, the titration schedule differs, ultimately reaching maintenance doses up to 2.4 mg weekly

Approved indications for GLP-1s: Cardiovascular disease Chronic kidney disease Obesity Sleep apnea Type 2 diabetes Metabolic dysfunction-associated steatohepatitis (MASH) Potential future indications: (indications with asterisks have already been investigated in randomized clinical trials) Substance use disorders (alcohol, tobacco) Alzheimers Parkinsons Cancer prevention Diabetes prevention* Diabetic retinopathy Heart failure* Osteoarthritis* Peripheral artery disease* Polycystic ovarian syndrome Psoriasis When I was at the ADAs 85th Scientific Sessions this year, what was quite apparent was just how quickly the field has progressed beyond GLP-1s

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