Compared to SERT alone, there was a significant increase with SILY 140 and SILY 280
In Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline 592 (National Academies Press, 1998)
doi: 10.1016/j.tem.2018.09.001 32 PaniAGiossiRMenichelliDFittipaldoVAAgnelliFIngleseEet al
danuglipron oral GLP-1 discontinued 2024 Key Peptide Products: Somavert (pegvisomant GH receptor antagonist), Genotropin (somatropin growth hormone peptide), BNT116/mRNA oncology vaccines, historical insulin franchise, Lupron (leuprolide US rights via Abbvie partnership) Therapeutic Segments: Oncology (Ibrance, Xtandi partnership, Padcev, Lorbrena)
An acute toxic dose has not been established but it is known that vitamin B6 may cause neurotoxicity at a dose of 300 to 500 mg per day over time