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Research has explored its interactions with extracellular matrix remodeling, collagen synthesis pathways, and cellular defense mechanisms linked to tissue maintenance and regeneration
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Necchi V, Candusso ME, Tava F, et al
While normally, autophagy is believed to have a protective effect on injured hepatocytes, recent studies demonstrate that ER stress signals activate autophagy and a profibrogenic phenotype in HSCs (Mallat et al., 2014)
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