Moreover, epidemiological studies document a significant association between ASD and autoimmune disorders such as celiac disease, type 1 diabetes, asthma, multiple sclerosis [143], epilepsy, and atopic disease [126, 524]
Notably, mutant DISC1 dysregulated expression of genes related to synapses, nervous system development, dendritic spine function pathways and psychiatric disorders in human forebrain neurons [161]
189 Further, ME1 treated with the inhibitor (piperazine-1-pyrrolidine-2,5-dione) has little effect on normal rat intestinal epithelial cells but strongly suppresses human CRC cell growth by targeting ME1 NADP + -binding site and reducing the NADPH level
Source: Hwang, et al JAMA Health Forum March 14, 2025 Implications for employers: This modeled study suggests that employers should at least offer access to the two combination generic medications for obesity if budgets allow
In research it is studied for sleep-architecture pathway research, hypothalamic-pituitary axis modulation, and stress-response signaling