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At 12 mg, TRIUMPH-4 also saw more dysesthesia (skin tingling/ numbness, 20.9% vs 8.8% at 9 mg) and more discontinuations for side effects (18.2% vs 12.2%) the extra ~2.3 points of weight loss over 9 mg is a tolerability trade-off

Preclinical studies demonstrate that sustained GLP-1 receptor activation alters mesolimbic dopamine signaling over a period of time, and emerging studies suggest that behavioral and craving-related effects require continued exposure (26, 27)

Acta 1842 , 12821294 (2014)

Emerging studies have further shown that CYP51A1 interacts with enzymes involved in lipid metabolism and participates in the regulation of cell death pathways, including ferroptosis and responses to SARS-CoV-2 infection, underscoring its involvement in both metabolic and immunopathological processes [50, 51]

Foundayo reached 11% over 72 weeks in a separate study