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For data analysis, 10 to 15 images per sample were processed in FIJI/ImageJ (National Institutes of Health, NIH) with unsigned 16-bit image range and a linear LUT

Sleep deprivation increases ghrelin (hunger hormone) and decreases leptin (satiety hormone), mimicking the exact hormonal environment that drives post-medication weight regain

Retatrutide represents the most powerful weight loss compound currently in clinical trials, with participants losing an average of 24.2% of their body weight over 48 weeks

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