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Description

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The acquired resistance of tumor cells to TKIs is partially reversed by inhibiting IGFBP-1 and the combination of antiangiogenic TKIs and IGFBP-1 inhibitors may be a promising therapeutic strategy for HCC (135)

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We evaluated the renal cell death by focusing on the RNA expression of apoptosis indicators Bcl-2, Caspase-9, and biomarkers of nephropathy (NGAL, KIM-1)