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Diabetes Care 35:12251231 Russell-Jones D, Cuddihy RM, Hanefeld M et al (2012) Efficacy and safety of exenatide once weekly versus metformin, pioglitazone, and sitagliptin used as monotherapy in drug-naive patients with type 2 diabetes (DURATION-4): a 26-week double-blind study
Closes the cortisol and nervous-system pathway that keeps the flushing going (HPA-axis pattern)
Whether you are looking for better blood sugar control or seeking to shed stubborn weight, the question of whether to stay on metformin while starting a GLP-1 medication is a common one
The duration of storage outside recommended temperature ranges should be documented, and the pharmacy should be consulted about whether the medication remains safe to use based on the specific conditions and duration of improper storage
Community protocols commonly use a 5-on / 2-off rhythm for CJC/Ipa to reduce receptor desensitization and provide a recovery window
