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Metabolites 9, 195
Administered via subcutaneous injection
Indications: Overactive bladder Common symptoms include urgency, urinary incontinence, and increased urinary frequency Side Effects: dry mouth constipation headache urinary tract infection angioedema CNS side effects (confusion, hallucinations, sedation) aggravation of decreased GI motility in patients with GI obstructive disorders Pharmacokinetics: taken orally by extended release tablet, 7.5 or 15 mg once daily metabolized by CYP3A4 & CYP2D6 half life 13-19 hrs Notes: the estimated Walmart cost for generic darifenacin is ~$71 for a supply of 30 generic 15 mg tablets (GoodRx.com
Chopra K, Tiwari V
Collectively, these effects may contribute to weight loss post-surgery in obese patients, suggesting the functional use of tripeptides for weight loss [182]
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