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Evaluation of energy and glucose homeostasis The body weight of AgRP GHR KO, LepR GHR KO and brain GHR KO mice, as well as of their respective control animals, was monitored weekly
Kishimoto A, Imaizumi A, Wada H, Yamakage H, Satoh-Asahara N, Hashimoto T, et al
The activation of PLC results in the release of inositol-1,4,5-trisphosphate (IP 3 ) from membrane associated phosphatidylinositol-4,5-bisphosphate (PIP 2 ), which then binds to specific IP 3 receptors in the endoplasmic reticulum/sarcoplasmic reticulum (ER/SR) resulting in the release of intracellular stores of Ca 2+
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