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For diabetic wound healing, which is notoriously slow and prone to complications, GHK-Cu incorporated into collagen dressings produced dramatically better outcomes: higher glutathione and ascorbic acid levels at the wound site, better epithelialization, and significantly more active fibroblasts and mast cells compared to standard dressings

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29 Despite these insights, DDR-targeted therapies remain challenged by nonselective toxicity, resistance heterogeneity, limited biomarker availability and modest clinical durability