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The Journal of Pharmacology and Experimental Therapeutics issued an Expression of Concern in 2021 (PMID: 34551989) for the McCoy et al
Aim for at least 64 ounces of water daily Time your injection so that the first 24 to 48 hours (when side effects peak) fall on days when you can rest
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Furthermore, a network meta-analysis examining the effects of GLP-1 RA therapy on body composition reported a greater reduction in lean body mass in the intervention group compared with placebo or active comparators (mean difference = 0.86 kg, 95%CI: 1.30, 0.42)
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