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Neurosci Bull 41(4): 676690

[7] Both metformin and GLP-1RAs are known to improve leptin sensitivity, making the brain more responsive to the anorexigenic effects of the adipokine

It plays a key role in regulating blood sugar, slowing gastric emptying, increasing insulin secretion, and promoting feelings of fullness

The primary mechanism involves stimulating insulin secretion from pancreatic beta cells in a glucose-dependent manner, meaning they only promote insulin release when blood glucose levels are elevated

Real-world data confirms these results persist when patients maintain medication use and lifestyle modifications