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Pharmacologic approaches to glycemic treatment: Standards of Medical Care in Diabetes 2024
Months 6-12: Approaching or reaching goal weight (30-50+ pounds total), metabolic improvements sustained, transition to maintenance planning, established healthier habits
GLP-1 semaglutideMACE 26%liraglutidedulaglutideMACE 12%exenatidelixisenatide orforglipron semaglutide 26%liraglutide GLP-1 GLP-1 GLP-1 GLP-1 receptor agonists-1 [4][9][5] HbA1c 0.4% 0.8%[4][5] [4] GLP-1 MACE 12% 14% 13% 14% 12% 13% 17% 11% 14%[1][2][3] 10% 14% [1][3] 1.06 0.85 1.34[1] semaglutideSUSTAIN-6 MACE 26% 83% [4][5] dulaglutide MACE[7] LiraglutideLEADER [4][5] dulaglutide 0.69[6] DulaglutideREWIND MACE 12%[3] semaglutidePIONEER 6 [4][3] Albiglutide efpeglenatide MACE 0.78 0.73 efpeglenatide [3] ExenatideEXSCEL lixisenatideELIXA MACE [3] semaglutide 2.4 MACE[4][2] 29 MACE[9] SGLT2 GLP-1 semaglutide liraglutide [7] liraglutidesemaglutidedulaglutide liraglutide [6] SGLT2 [8] exenatide [3] semaglutideMACE 26%liraglutidedulaglutideMACE 12%[4][5][3] [4] semaglutideliraglutidedulaglutideexenatidelixisenatide [3] orforglipron GLP-1 orforglipron GLP-1semaglutideliraglutidedulaglutide SGLT2 [8] orforglipron 0.4% 0.8%[4][5][4][9][5] semaglutideMACE 26%liraglutidedulaglutideMACE 12%exenatidelixisenatide orforglipron A better life begins with health Marsico F, Paolillo S, Gargiulo P, et al
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Understanding the difference between a triple agonist vs dual agonist is essential for researchers evaluating these compounds
