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While GLP-1RA monotherapy may be sufficient for many patients, particularly those without renal risk, combination therapy may be particularly beneficial for high-risk subgroups, such as those with CKD

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They reduce appetite from different receptor systems, which is precisely why an amylin analog is studied alongside a GLP-1 analog in CagriSema rather than as a substitute for one

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Thus, we multiply the V max values of GCL and GPX by a number, S , where S = 1 for males and S = 1.8 for females

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