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Ultimately, further research is warranted to fully understand the effect of glutathione-rich foods on oxidative stress and glutathione levels

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although its chemical activity is similar to the original drug, MTX-PG 2-6 is preferentially kept in the intracellular environment [whereas non-glutamylated MTX is quickly exported by ABC transporters (8)], and cellular sensitivity to MTX is directly related to the intracellular pool of MTX-PGs (9)

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