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Researchers continue to investigate its influence on dermal papilla cell signaling, extracellular matrix regulation, angiogenic signaling, and the biological pathways that support normal hair follicle function and skin physiology

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DBS efficacy has improved with adaptive stimulation protocols 28 and advanced neuroimaging 29 , but existing targets have shown limited success in improving levodopa-resistant freezing of gait and may lead to adverse effects, such as cognitive impairment 26,30