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[6] While this increase is generally well-tolerated, it has raised questions among clinicians and patients about the underlying mechanisms and clinical implications

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The calculator focuses on mean trajectories rather than minimum or maximum values, as individual extremes are not consistently published in trial sources

The DAPA-CKD (Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidney Disease) trial specifically included patients with chronic kidney disease with or without diabetes to receive dapagliflozin and found that these patients experienced a lower risk of ESRD, GFR decline of at least 50%, or death from renal or cardiovascular causes in comparison to placebo [31]

Which GLP-1 Has the Least Side Effects in the UK