10.1016/S0887-8994(97)00026-X Matsumoto J, Ogawa H, Maeyama R, Okudaira K, Shinka T, Kuhara T, Matsumoto I: Successful treatment by direct hemop-erfusion of coma possibly resulting from mitochondrial dysfunction in acute valproate intoxication
Savikj M, Stocks B, Sato S, Caidahl K, Krook A, Deshmukh AS, et al
During this process, the recruitment of glucose-regulated protein 78 (GPR78, also known as BiP) results in the activations of inositol requiring enzyme-1 (IRE1), PKR-like ER kinase (PERK), and activating transcription factor 6 (ATF6), which inhibit protein translation, promote ER chaperones, and thus, reduce unfolded protein levels [140]
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Metformin has been around longer