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Quality of life is significantly impacted by both early and late, and management is difficult, usually given in stepwise approach of dietary, medical or surgical re-intervention options [12]

As such, glomerular lesions occur which include glomerular basement membrane thickening, podocyte effacement and loss, mesangial expansion, epithelialmesenchymal transition EMT and fibrosis, collagen deposition, damage to the capillary architecture and an influx of inflammatory cells including macrophages