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GLP-1 receptor activation The GLP-1 component of retatrutide reduces appetite through multiple mechanisms: slowing gastric emptying (food stays in your stomach longer, so you feel full sooner), signaling satiety centers in the brain (your brain gets a stronger "stop eating" signal), and enhancing insulin secretion in response to meals
Potential side effects include: Mild irritation: These typically include redness, itching, or tingling, especially the first time peptides are used
The initial dose is 10 mcg once daily subcutaneously for 14 days, on the 15 th day the dose is increased to 20 mcg once daily subcutaneously
(2023) "Pharmacotherapy of obesity: an update on the available medications and drugs under investigation" eClinicalMedicine, 58, 101882 5
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