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Activation, mtDNA, particularly in its oxidized form (ox-mtDNA), can also directly activate the NLRP3 inflammasome, promoting caspase-1 activation, maturation of IL-1 and IL-18, and GSDMD (Gasdermin D)-mediated pyroptosis, thereby fueling chronic inflammation (77, 78)
Some individuals also report changes in food cravings or preferences
Role of M1-polarized tumor-associated macrophages in the prognosis of advanced ovarian cancer patients
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