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Journal of Biological Chemistry, 301(1), 108047
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So for STEP HFpEF Diabetes trial, patients that had documented HFpEF with additional kind of enhancing features and a BMI of 30 and above were randomly assigned to either semaglutide with a target dose of 2.4 milligrammes once a week or matching placebo and treated for 52 weeks and the two dual primary endpoints were a change in the Kansas City Cardiomyopathy questionnaire, which is the gold standard of evaluating heart failure related symptoms and physical limitations, and the second was change in body weight and we also had a number of confirmatory secondary endpoints including looking at exercise function with six minute walking distance hierarchical composite, which also integrated clinical events, like death and heart failure, hospitalizations and urgent visits, in addition to KCCQ on six minute walking distance and also changes in CRP, which is a marker of inflammation
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