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Exposure to ionizing radiation is well known to promote oxygen radical formation within biological systems through radiolysis (interaction of radiation and water).12 Hypoxia or/and hyperoxia condition in cells has been noted to generate numerous oxygen-derived radicals.13 Besides, a couple of therapeutic drugs such as acetaminophen have been reported to cause oxidizing effects on cells, consequently leading to formation of oxygen radicals through the activity of drug metabolizing enzymes known as cytochrome P -450 system.14 5
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Proteins can unfold and lose their biological activity when subjected to mechanical stress
Lund A, Vilsboll T, Bagger JI, Holst JJ, Knop FK (2011) The separate and combined impact of the intestinal hormones, GIP, GLP-1 and GLP-2, on glucagon secretion in type 2 diabetes
The introduction of a powerful medication that lowers glucose levels may disrupt the delicate balance in these eyes
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