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IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone

So, again, a lot of unknowns.

So, fenugreek flopped, but there are some spices that can legitimately boost GLP-1 in humans

Slowed Gastric Emptying and Fullness Signals GLP-1 medications also slow how quickly food leaves the stomach (gastric emptying)

They'll serve different niches: CagriSema Will Dominate: Patients familiar with Wegovy brand Those wanting proven semaglutide component People with type 2 diabetes (strong REIMAGINE data) Earlier availability (mid-2027) Retatrutide Will Dominate: Patients needing maximum weight loss (BMI 40) Those with multiple complications (OA + OSA + obesity) People who failed CagriSema Willingness to wait for highest efficacy Tirzepatide (Zepbound) Will Remain Relevant: Already available NOW Proven safety with 22.5% weight loss Lower cost than either new option Established insurance coverage The High-Dose CagriSema Wildcard Novo Nordisk announced plans for CagriSema 2.4mg/7.2mg trials starting late 2026tripling the cagrilintide dose