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In mouse studies, researchers reported improved health markers rather than obvious toxicity, but mouse safety does not predict human safety
Myasthenia Gravis (noted in moderate-to-severe orbitopathy) Severe corneal exposure, optic nerve compression Nerve Compression Brachial Plexus Injuries (sight threatening) Myxedema Myxedema A condition characterized by a dry, waxy type of swelling (edema) with abnormal deposits of mucopolysaccharides in the skin and other tissues
doi: 10.1136/annrheumdis-2012-201526 294 KarouzakisERazaKKollingCBuckleyCDGaySFilerAet al
It is investigated in experimental models for its interaction with growth factor signaling, angiogenesis-related mechanisms, and cytoprotective processes
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