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186 These alterations underlie resistance not only to cytotoxic chemotherapy and radiotherapy but also to molecularly targeted agents and immunotherapies
Glutathione: The Master Antioxidant Glutathione (GSH) is the molecule your cells rely on to stay young and functional
140 For instance, decreased expression of the organic cation transporter OCT2 (SLC22A2) confers resistance to platinum-based drugs in pancreatic and ovarian cancers by reducing cellular drug accumulation
Smoking also increases risk by reducing blood flow to spinal structures and impairing tissue repair
