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X-ray crystallography and NMR spectroscopy have established that copper coordinates through a 3N1O equatorial square-planar pyramid configuration: the histidine imidazole nitrogen, the glycine -amino nitrogen, and the deprotonated amide nitrogen of the glycine-histidine peptide bond, with additional oxygen coordination from neighboring complex carboxyl groups

Additionally, research into novel delivery technologies, such as microneedle patches and implantable devices, holds the potential to further enhance patient convenience and compliance, thereby expanding the market reach and attractiveness of GLP-1 receptor agonists

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