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It has also been reported that cholesteryl ester transfer protein (CETP) can transport cholesterol from high-density lipoprotein to lipoprotein containing apolipoprotein B (ApoB) and rich in TG, such as chylomicron remains (containing ApoB-48) and VLDL remains (containing ApoB-100)

Li, J.-R., Cao, J., Wei, J

The dual agonist approach represented by tirzepatide demonstrates that activating multiple complementary pathways produces superior results to targeting a single pathway, even when that single pathway works quite well on its own